What Do You Know About Synthetic Semax Peptides?

Semax is a type of nootropic medication for improving various cognitive functions. It is a synthetic version of an endogenous hormone called adrenocorticotropic hormone (ACTH). Though our body produces many peptides that help in regulating daily bodily functions, they are highly unstable. It is arduous to balance the number of endogenous peptides as it is prone to break down under various biological enzymes found in our body. Thus, there is a need for synthetic peptides.

The anterior pituitary gland secretes the ACTH containing the peptide fragment, which has a special effect on the brain. It can boost your memory and improve your attention. Semax has similar effects being its analog. Therefore, many drugs for treating CNS diseases use Semax considering the benefits with minimum side effects.

How Does Semax Work?

Though you may find Semax for sale, it is tough to find accurate information on how it works on the human body. There are many theories related to its functioning. One such theory says that Semax escalates brain-derived neurotrophic factor (BDNF) level. These BDNFs are the most active neurotrophins that regulate and stimulate the process of neurogenesis. So, BDNF would help in cell regeneration, healing, and protection of the existing nerve cells.

Semax also controls the breakdown of enkephalins which reduces inflammation and pain, boosts immunity, and inhibits cancer cell growth. They also impact learning, memory, and emotional development. 

A well-balanced enkephalin level is necessary for normal brain functioning. These reasons make researchers more interested in its potential to contribute to the treatment of various diseases and disorders related to brain function and cognitive health.

Research And Studies on Semax

There have been many clinical studies and research on Semax to date. They researched its nootropic and neuroprotective properties and other effects like altering the fluvoxamine-induced conditions; prevention of cardiovascular failure; and reducing symptoms of neonatal maternal deprivation.

The nootropic effect on the healthy male participants of a clinical trial in Russia showed that administration of 0.015 to 0.050 mg/kg is effective just after 24 hours. The test subjects displayed more attentive memory and concentration. 

The previous studies even indicate that this drug doesn’t have any negative effects and is tolerable. However, we would need more evidence to justify its therapeutic effect on all.

Benefits Of Semax Peptide

Here are some of the benefits of the use of Semax peptide –

  • Analgesic properties with the increased level of enkephalin
  • Enhanced memory with regulated mood
  • Improved circulatory system
  • Regulates the stress response
  • Effective treatment of ADHD symptoms
  • Protection of cardiovascular system in case of strokes or failure

Potential Side Effects

Although the current studies do not show any potential side effects related particularly to semax peptide, there are some common side effects generally with peptides –

  • Nausea
  • Dizziness
  • Vomiting tendency
  • Lack of energy
  • Pain, redness, or swelling (in case of administration with injection)
  • Symptoms of flu

Since we don’t have fully furnished data, it is difficult to determine the exact side effects. You may have side effects other than those mentioned here.

Administration And Dosage of Semax

The correct dosage of semax depends on the purpose of its use. A low dose of 5 to 50 mcg per kg body weight would give an antioxidant effect, whereas high doses might increase oxidative stress. Even different ways of administration have different duration of action on the body. 

The intranasal administration effects are short-lived compared to injections. You would like to start with a low dose and slowly increase the dosage according to effectiveness. The normal range would be between 300 mcg to 600 mcg.


Semax is beneficial in many ways, but remember that it is a prescribed drug. Consult your doctor to avoid any complications and adverse reactions.